A Study of Some Biochemical Parameters in COVID-19 Patients with Diabetes Mellitus: Comparative Study
DOI:
https://doi.org/10.51173/jt.v4i33.638Keywords:
Type 2 diabetic mellitus, Non-diabetic mellitus, HbA1c, Uric acid, Creatinin, Ferritin, D-dimerAbstract
COVID-l9 is considered a global health emergency, this disease affects all individuals and its symptoms are similar to the common cold. The purpose of this study is to compare diabetic and non-diabetic patients in some biochemical tests of patients infected with COVID-l9. Of the l20 patients included in the study, 7l patients were males (59.l7%) and 49 were females (40.83%). The study showed that the highest percentage was in males with diabetes (63.33%), followed by non-diabetics (55.00%), without significant difference. As for the age group, most patients were over 50 years, and it was most common among non-diabetics in addition to diabetes. Mean glucose was significantly different between the diabetic group and the non-diabetic group. For the diabetic group, the mean blood sugar was 229.22 ± 82.25mg/dl, while the mean blood sugar in the non-diabetic group was l32.25 ± 44.08 mg/dl. In addition, there was a significant difference in mean HbA1c between the diabetic and non-diabetic groups p < .001. For the diabetic group, the mean HbA1c was 7.5l ± l.27 %, but in the non-diabetic group, the mean HbA1c was 5.41 ± 0.73%. While there was a significant difference between the two groups with and without diabetes in the mean ferritin ratio p < .00l. For the diabetic group, the mean serum ferritin was 638.78 ± 327.78 ng/ml, although in the non-diabetic group, the mean serum ferritin was 393.74 ± 330.83 ng/ml. There were no significant differences between the diabetic and non-diabetic group in the mean of D-dimer, urea, creatinine and uric acid, in the diabetic groups, the mean was 6.00 ± 5.80 ug/ml, 86.02 ± 64.27 mg/dl, 1.64+1.45mg/dl and 5.37 ± 3.11mg/dl, respectively. While in the non-diabetic group, the mean was 5.82 ± 5.76 ug/ml, 74.68 ± 68.27mg/dl, 1.88 ± 2.62 mg/dl, and 4.86 ± 2.62 mg/dl, respectively.
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H.X. Xiang , J. Fei , Y. Xiang, Z. Xu , L. Zheng , X.Y Li , L. Fu, and H. Zhao,” Renal dysfunction and prognosis of COVID19 patients: a hospital-based retrospective cohort study” BMC Infectious Diseases Vol. 21, P.158 https://doi.org/10.1186/s12879-021-05861-x . Open Access, 2021.
A.R Sarhan, M.H Flaih., T.A. Hussein and Kh.R Hussein, ”Novel coronavirus (COVID-19) Outbreak in Iraq: The First Wave and Future Scenario.Cold spring harbor laboratory” BMJ. doi: https://doi.org/10.1101/2020.06.23.20138370, (2020).
C. Huang, Y. Wang, X. Li, L. Ren, J .Zhao, Y. Hu, et al.” Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.” Lancet.; Vol. 395 , P. 497-506, 2020.
Y.M Liu., X J. Jing, M.M. Chen, X. Zhang, X. Cheng, H. Li, Z F. Feng, J.J. Qin, F. Lei, Z. Chen, L. Lin, Ch. Yang, W. Mao, G., Lu H. Chen, X. Xia, D. Wang, X. Liao, J., X H. Yang, B. H. Zhang, C. Yuan, J Cai., X.J. Zhang, Y. Wang, X Zhang, Z.G. She, and H Li.,”Kidney Function Indicators Predict Adverse Outcomes of COVID-19” Med Vol. 2,P. 38–48, Elsevier Inc. Clinical and Translational Article, January 15, 2021 ª 2020.
J. Qu, H.H Zhu., X.J. Huang, G.F. He, J.Y. Liu, J.J Huang., Y. Chen, Q. Qu, Y.L., X.Y. Chen, Q. Lu, “Abnormal Indexes of Liver and Kidney Injury Markers Predict Severity in COVID-19 Patients. Infection and Drug Resistance. Dovepress. Infection and Drug Resistance”:Vol.14,P. 3029–3040, 2021.
A. V Matuleviciene., A Rosengren, AM. Svensson, A Pivodic., S. Gudbjörnsdottir, H. Wedel et al., “Glycaemic control and excess risk of major coronary events in persons with type 1 diabetes”, Heart. vol. 103, no. 21: pp.1687- 95 ,( 2017).
N. Abbaspour, R. Hurrell, R. Kelishadi, “Review on iron and its importance for human health”. Research J Med Sci:Vol. 19,N. 2, P.164–74, (2014).
M Kumar, CM. Bindu, AC. Shyam , R. Reena, ”Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19”. ASIAN JOURNAL OF MEDICAL SCIENCES, Vol 12 Issue 12. , Dec 2021.
A.R Sarhan., M.H. Flaih, T.A. Hussein and Kh.R Hussein”Novel coronavirus (COVID-19) Outbreak in Iraq: The First Wave and Future Scenario.Cold spring harbor laboratory”. BMJ. doi: https://doi.org/10.1101/2020.06.23.20138370 , 2020.
A.H. Ad’hiah , N.T Al Bayatee and A.A. Ahmed ,”Coronavirus disease 19 and risk of hyperglycemia among Iraqi patient”. https://doi.org/10.1186/s43042-021-00207-3 . Egyptian Journal of Medical Human Genetics, 2021.
S.A. Mohammed , S.H. Ahmed, A.I.O. Al- Saadaw., M.M Mohamm,”An Observational Study Of Coronavirus (Covid-19) In Iraqi Patients At Al-Shifa Medical Center In Baghdad's Capital, Al-Rusaf”. Sys Rev Pharm ,Vol. 11, N.11,P. 404-411 A multifaceted review journal in the field of pharmacy ,2020.
J.P. Pangaribuan, M.A. Pase, “Correlation between Hblc and D-dimer in Type 2 Diabetic with COVID-19 Patients” Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI), Vol. 03, No. 4, P. 145-151, 2021.
S. Yuan, H. Li, Ch. Chen, F. Wang, D.W. Wang,”Association of glycosylated haemoglobin Hblc levels with outcome in patients with COVID-19”: A Retrospective Study. J Cell Mol Med, Vol. 25, P.3484–3497, 2021.
V. Vargas et al.”Ferritin levels and COVID-19” Rev Panam Salud Publica 44, www.paho.org/journal https://doi.org/10.26633/RPSP.2020.72 ,(2020).
American Diabetes Association ” How COVID-19 Impacts People with Diabetes”. Available at: https://www.diabetes.org/corona virus-covid-19/ how-coronavirus-impacts-people-with-diabetes Accessed May 22, (2020).
M. Kumar., CM .Bindu, AC. Shyam, R Reena, ”Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19”. Asian Journal of Medical Sciences , Vol. 12 ,Issue 12,Dec. 2021.
C. Qin, L Zhou., Z Hu., et al.” Dysregulation of immune response in patients with COVID-19 in Wuhan, China”. Clin Infect Dis ,Vol. 53, P 1689–1699, 2020.
JJ. Zhang, X Dong., YY Cao., YD Yuan., YB. Yang, YQ Yan., et al. “Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China” Allergy;. https://doi.org/10.1111/all.14238 ,Vol.75, N. 17, P.30–41,2020.
CM Petrilli., SA Jones., J Yang., et al. “Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study”. BMJ. doi:10.1136/bmj.m1966, 2020.
N Tang., D. Li, X. Wang, Z. Sun, “Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia”. J Thromb Haemost.;. doi:10.1111/ jth.14768, Vol.18 ,No 4, P. 844–847 ,2020.
R. Al Argan, D. Alkhafaji, Al E. Abdulmohsen , W. Albaker, et al,,”The Impact of Diabetes Mellitus and Hyperglycemia on the Severity and Outcome of Patients with COVID-19 Disease: A Single-Center Experience”. International Journal of General Medicine. O R I G I N A L R E S E A R C H, .,(2021).
M. Apicella, MC Campopiano., M Mantuano, L. Mazoni, A. Coppelli and S. Del Prato” COVID-19 in people with diabetes: understanding the reasons for worse outcomes”. Lancet Diabetes Endocrinoldoi:10.1016/S2213-8587(20)30238-2, Vol.8, N.9, P. 782–792. (2020).
M. Murea “Advanced kidney failure and hyperuricemia”. Adv Chronic Kidney Dis, doi:10.1053/j.ackd.2012.07.008, Vol. 19 ,N.6, P. 419–424. 2012.
R. Shi, Z. Niu, B Wu., F. Hu, ”Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus”. Risk Management and Healthcare Policy, Vol. 13, P.1661–1675.Dovpress., (2020).
Sh. K. Luo, W.H. Hu, Z.J. Lu, Ch. Li, Y.M. Fan, Q.J. Chen, Z.Sh. Chen, J.F. Ye, Sh.Y Chen., J.L. Tong, L.L. Wang, J. Mei, H.Y. Lu, ”Diabetes patients with comorbidities had unfavorable outcomes following COVID-19: A retrospective study. World Journal of W J D Diabetes. Submit a Manuscript: https://www.f6publishing.com World J Diabetes ,Vol.12, N. 10, P. 1789-1808 DOI: 10.4239/wjd.v12.i10.1789 ISSN 1948-9358 (online), October 15 ,2021.
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