Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability

Adil Elrayah; Ke Duan; Xiong Lu; Xiaob Lu; Jie Weng

doi:10.51173/jt.v6i2.2545

Authors

Adil Elrayah Medicine Collage, Karary University, Omdurman 12304, Sudan
Ke Duan Key Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China
Xiong Lu Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
Xiaob Lu Key Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China
Jie Weng Key Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China

DOI:

https://doi.org/10.51173/jt.v6i2.2545

Keywords:

Hydroxyapatite, Micro/Nano-Structure, Scaffolds, Coating, Endothelial Cell

Abstract

Hydroxyapatite (HA) scaffolds produced by the accumulation of HA fibers were separately treated hydrothermally in three calcium phosphate solutions to form coatings of different micro/nano-structures. Different micro/nano-structure and morphologies have been regulated on the surface of treated HA scaffolds. Plate-like compromise flower-like morphology was obtained with solution 1 (Ca-sufficient) i.e., ratio: Ca/Ca=1%; Ca/P=1.67. Full coatings (flower-like) morphology treated after Cu-doped coating solution 2 (Cu/(Cu+Ca) = 5%; ratio: (Cu+Ca)/P = 1.67). Furthermore, partial coatings (flower-like) morphology fabricated with solution 3 (Ca-deficient and Cu-replacement), i.e., ratio: Ca/Ca=0.95%; Ca/P=1.58. The results showed the effect of hydrothermal coatings on HA scaffolds. Cultured human endothelial cells spread and proliferated better on the treated HA scaffolds than on the uncoated scaffolds, suggesting a potential effect of calcium phosphate surface morphology on endothelial cell response. Thus, it can provide an appropriate micro/nano-structure approach supporting angiogenesis capacity, which is a necessity to accelerate the time of bone healing and regeneration.

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Author Biographies

Adil Elrayah, Medicine Collage, Karary University, Omdurman 12304, Sudan

Ke Duan, Key Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China

Xiong Lu, Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Xiaob Lu, Key Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China

Jie Weng, Key Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China

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