Histopathological Study of Bee Venom with Different Concentrations in Laboratory Mice

Zeyad G. Al-Rikabi; Montaha Abdulkareem Al-Saffar; Huda S. Nassir; Inam B. Falih

doi:10.51173/jt.v3i4.389

Authors

Zeyad G. Al-Rikabi Ministry of Science and Technology, Environment and Water Directorate, Baghdad / Iraq.
Montaha Abdulkareem Al-Saffar Department of Community Health, Medical Technical Institute- Baghdad, Middle Technical University, Baghdad, Iraq
Huda S. Nassir Ministry of Science and Technology, Environment and Water Directorate, Baghdad / Iraq.
Inam B. Falih College of Veterinary Medicine, University of Baghdad, Baghdad / Iraq

DOI:

https://doi.org/10.51173/jt.v3i4.389

Keywords:

Kidney, Liver, Melittin, Histopathology, Bee Venom

Abstract

Bee venom (BV) of Apis mellifer L has recently been utilized as a traditional medicine for treating a variety of medical conditions. When mice were given different concentrations of bee venom, it was found to be effective in repairing some histopathological changes. Then, when applying BV as a treatment material for some disorders, as indicated by the amount of damage to the liver and kidney tissues. The animals were randomly divided into 7 groups. Six of which were treated with BV extraction, and one group was designated as the control group, was treated with distilled water. Mice were injected intraperitoneally by 0.2ml of BV extraction in concentrations (1000, 750, 500, 350, 300, and 250) μg/ml. In some cases, histopathological studies revealed mild to moderate alterations in the liver and renal tissues, characterized by congestion, acute cell swelling, and focal coagulated necrosis. Atherosclerotic changes in the aorta and some arteries were found in two groups. Whereas several mild degenerative changes were observed in hepatic cells of one group. In conclusion, bee venom administered to groups in different concentrations revealed hepatic and renal complications at histological investigations of hematoxylin and eosin-stained sections of liver and kidney section.

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