Liver damage during infections with coronavirus
Abstract
The pathogen of the new 2019 coronavirus disease (COVID-19), the sever acute respiratory syndrome coronavirus 2 (SARS-Cov-2), presented a significant risk to health care. The WHO has described the SARS-CoV-2 infection outbreak as an international public health emergency. The main damage caused by the infection with SARS-CoV-2 was known to be lung infections. Previous research revealed that liver damage is prevalent in patients infected with the additional widely zoonotic coronaviruses, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), and has been reviewed in relation to the severity of MERS, SARS, and COVID-19 diseases. Likewise, the mechanism and features of liver damage and liver injury has also been observed, as outlined in this review, which results in extreme cases during the phases of the disease.
References
N .Zhu, D. Zhang, W. Wang, L. xingwang, B. Yang, S. Jingdong , et al., “A novel coronavirus from patients with pneumonia in China, 2019”, The New England Journal of Medicine ,vol. 382, No. 2, pp. 727–33, Jan 2020.
D. Hui, I. Azhar ,T. Madani, F. Ntoumi,R. Kock ,O. Dar ,et al., “The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: the latest 2019 novel coronavirus outbreak in Wuhan, China”, International journal of infectious diseases , vol.91,No.5, pp.:264-266, Jun 2020.
I. Esam ,.S. David ,C.Hui, A. Ziad ,D. Christian,Z.Alimuddin, et.al., “ The Middle East Respiratory Syndrome (MERS)”, Infectious Disease Clinics of North America , vol. 33, No. 4, pp.891-905, Dec 2019.
N. Chen, M. Zhou, J.Qu X. Dong, F.Gong, Y.Han, et.al., “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study” ,The Lancet ,vol.395,No.3, pp. 507–513, Jan 2020.
Z. Xu, L. Shi, Y. Wang, J. Zhang ,L. Huang , C. Zhang, et.al., “Pathological findings of COVID-19 associated with acute respiratory distress syndrome” ,The Lancet Respiratory Medicine ,vol. 8,No.4,pp. 420–22,Feb 2020
T. Chau , K. Lee, and H.Yao, “SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases” , Hepatology, vol. 39, No.2,pp.302–310,Feb 2004.
S. Mallapaty ,” Why does the coronavirus spread so easily between people?” Nature, vol.579, No.7798 ,p.183, 18,Mar 2020.
H. Zhang,H. Li, and J.Lyu, , “Specific ACE2 expression in small intestinal enterocytes cause gastrointestinal symptoms and injury after 2019-nCoV infection” , International journal of infectious diseases ,vol. 96, pp.19–24,Jul 2020,.
Q. Li, X.Guan, P. Wu ,X. Wang, L. Zhou, Y. Tong, et al., “Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia”, The New England Journal of Medicine,vol.382,No.13,pp.1199–1207,March 2020.
D. Wang, B.Hu, C.Hu, F. Zhu, X. Liu, J. Zhang, et al.,” Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China” , JAMA ,vol.323,No.11,pp.1061–1069,Feb 2020.
C.Yeo, S. Kaushal, and D. Yeo., “Enteric involvement of coronaviruses: is faecaloral transmission of SARS-CoV-2 possible?”, Lancet Gastroenterology Hepatol ,vol. 5,No. 4, pp.335–337,Apr.2020.
W. Zhang, R. Du, B. Li, X. Zheng,X. Yang, B. Hu, et al., “Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes”, Emerging Microbes &Infection ,vol.9,No.1,pp.386–389,Feb 2020.
C.Zhang, L.Shi, and F.Wang.,” Liver injury in COVID-19: management and challenges” The Lancet Gastroenterology& Hepatology ,vol. 5,No.5,pp.428–430,May 2020.
Z.Safiya, S.Jamie, and N.Mangala, , “Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area” , JAMA, vol.323,No.20,pp.2052-2059,Apr 2020.
W. Guan, Z.Ni, Y.Hu, W.Liang, C.Ou, J. He, et al.,” China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China” ,The New England Journal of Medicine ,vol.382,pp.1708–1720,Apr 2020.
D. Wang, B.Hu, C.Hu, F.Zhu,X. Liu, J.Zhang, et al., “Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China” , JAMA ,vol.323,No.11,pp.1061–1069,Feb 2020.
T. Chen, D.Wu, H.Chen, W.Yan, D.Yang, G.Chen, et al., “Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study” , BMJ ,vol.368,p.m1091,Mar 2020.
X. Xu, X.Wu, X.Jiang, K. Xu, L.Ying, C.Ma, et al., “Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series”, BMJ ,vol.368,p. m606,Feb 2020.
C. Zhang, L. Shi, F. Wang.,” Liver injury in COVID-19: management and challenges” The Lancet Gastroenterology& Hepatology ,vol.5,No.5,pp.428–430, March 2020.
N. Chen,M. Zhou, X. Dong, J. Qu, F.Gong, Y. Han, et al., “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study’ The Lancet ,vol.395,No.10223,pp.507–513,Jan 2020.
Z. Fan, L. Chen, J. Li, C. Tian, Y. Zhang, S.Huang, et al., “Clinical features of COVID-19 related liver damage” ,medRxiv,vol.9,No.33,pp.1-21, Feb 2020.
S. Alqahtani and J.Schattenberg, “Liver injury in COVID-19: The current evidence” ,United European Gastroenterol Journal, vol.8,No.5,pp.509–519, Jun 2020.
L. Xu, J.Liu, M.Lu, D.Yang, and X. Zheng , “Liver injury during highly pathogenic human coronavirus infections” ,Liver International, vol.40,No.5,pp.998–1004, May 2020.
Z. Xu, L.Shi, Y.Wang, J. Zhang, L. Huang, C. Zhang, et al., “ Pathological findings of COVID-19 associated with acute respiratory distress syndrome” ,The Lancet Respiratory Medicine ,vol.8,No4,pp.420–422, Feb 2020.
S. Tian, Y. Xiong, H. Liu, H. Niu, J. Guo, M. Liao, et al., “ Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies”, Modern Pathology ,vol.33,No.6,pp.1007–1014, Apr 2020.
Y. Zhang, L. Zheng, L.Liu, M.Zhao, J.Xiao, Q.Zhaome, et al. , “ Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single centre in Wuhan city, China” ,Liver International, ,vol. 40,No.9,pp.2095–103,Sep 2020.
M. Bangash, J.Pate and ,D. Parekh , “COVID-19 and the liver: little cause for concern”, The Lancet Gastroenterology& Hepatology ,vol. 5,No.6,pp.529–530, Mar 2020.
Y. Xiao, H. Pan, Q.She, et al.,” Prevention of SARS-CoV-2 infection in patients with decompensated cirrhosis” The Lancet Gastroenterology& Hepatology. ,vol. 5,No.6,pp. 528–529,Jun2020.
J. Qin , H.Wang, X.Qin, P.Zhang, L.Zhu, J.Cai, et al., “ Perioperative presentation of COVID-19 disease in a liver transplant recipient” , Hepatology , vol.72No.4,pp.1491-1493, Oct 2020.
L. D’Antiga,“Coronaviruses and immunosuppressed patients. The facts during the third epidemic”, Liver Transplantation ,vol.26,No.6,pp.832–834,Feb 2020.
G. Andrea, D.Daniele , A.Barbara, M. Davide, A.Laura , R. et.al., “Coronavirus disease 2019 and transplantation: A view from the inside” ,The American Society of Transplantation and the American Society of Transplant Surgeons,vol.20, pp.:1939–1940, May 2020.
C. Huang, Y. Wang, X. Li, L. Ren, J. Zhao, Y. Hu, et al., “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China” ,The Lancet ,vol.395,No.10223,pp.497–506,Feb 2020.
J. Chen, “Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses”, Emerging Microbes &Infection ,vol.22,No.2, pp.69–71,May 2020.
S. Lu, C.Lee and M. Lin, ”Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome” ,The American journal of tropical medicine and hygiene, vol.71, No.2,pp.125-128,Aug 2004.
H. Shi, X.Han and N.Jiang “Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study” , Lancet Infectious Disease,vol.20,No.4,pp.425-434, Apr 2020.
Q. Cai,D. Huang and P.Ou, “COVID-19 in a Designated Infectious Diseases HospitalOutside Hubei Province, China” , medRxiv ,vol.75,No.7, pp.1742-1752, Jul 2020.
L. Li, S. Li, M. Xu, L. Li L, S. Li, M. Xu, et al., “Risk factors related to hepatic injury in patients with corona virus disease 2019” ,medRxiv ,vol.2 ,pp.14-28 ,Mar 2020.
W. Cao , S.Li , C. Lin, X. Xuemei, W.Zirong., “Clinical features and laboratory inspection of novel coronavirus pneumonia (COVID-19) in Xiangyang, Hubei” ,medRxiv,vol.2,pp.25-36 ,Feb 2020.
X. Yang, Y.Yu and J.Xu, “Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study” ,The Lancet Respiratory Medicine,vol.8,No.5,pp.475-481,May 2020.
K. Alsaad, A.Hajeer, M. Al Balwi, et al., “ Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection clinicopathological and ultrastructural study” , Histopathology, vol.72,No.3,pp.516-524,Aug 2018.
H. Chang, K.Chen, S.Lai, H.Kuo, I.Su, R.Lin, et al., “Hematological and biochemical factors predicting SARS fatality in Taiwan” , Journal of the Formosan Medical Association, vol.105,No.6 ,pp. 439–450, Jun 2006.
H. Chan, A.Kwan, K.To, S.Lai, P.Chan, W.Leung, et al,. “Clinical significance of hepatic derangement in severe acute respiratory syndrome” , World journal of gastroenterology ,vol.11,No.14,pp.2148–2153,Apr 2005.
Z. Yang, M. Xu, J.Yi and W.Jia , “Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome” ,Hepatobiliary & pancreatic diseases international,vol.4,No.1, pp.60–63,Feb 2005.
K. Wu , S.Lu, C.Changchien, K.Chiu, C.Kuo, S. Chuah, et al., “Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome” ,The American journal of tropical medicine and hygiene, vol.71,No.2, pp.125–128, Aug 2004.
Z. Duan,Y. Chen, J. Zhang, J. Zhao, Z. Lang, F. Meng, et al., “Clinical characteristics and mechanism of liver injury in patients with severe acute respiratory syndrome” ,Zhonghua Gan Zang Bing Za Zhi ,vol.11,No. 8,pp.493–496,Aug 2003.
H. Chan, W.Leung, K.To, P.Chan,N. Lee,A. Wu, et al., “Retrospective analysis of liver function derangement in severe acute respiratory syndrome” ,The American journal of medicine , vol.116,No.8,pp.:566–567, Apr 2004.
J. Peiris,S. Lai, L.Poon, Y.Guan, L.Yam,W. Lim, et al., “SARS study group.Coronavirus as a possible cause of severe acute respiratory syndrome” ,The Lancet ,vol.361,No.9366,pp.1319–1325,Apr 2003.
H.Chang, K. Chen and S.Lai, “Hematological and biochemical factors predicting SARS fatality in Taiwan”, Journal of the Formosan Medical Association ,vol.105,No.6, pp. 439-450,Jun 2006.
Z. Liu and J.Guo, “ Dynamic changes of liver function and myocardial enzyme in 259 patients with severe acute respiratory syndrome” ,Journal of Clinical and Experimental Hepatology,vol.3,pp.:129-131,2003.
Y. Lu, C.Yin and X.Tang, “Clinical characteristics and mechanism of liver function injury in 250 patients with severe acute respiratory syndrome” ,Journal of Modern Medical Information Sciences, vol.23,pp.121-123,Jan 2004.
Z. Tie, T. Zhang and M.Zhang , “Prevention and treatment of liver injury in SARS patients-222 cases analysis” ,Beijing Medical Journal ,vol.5,pp. 318-320,Apr 2004 .
L. Zhao, H.Xing and L. Xu , “Effect of SARS associated coronavirus on peripheral blood picture and liver function.” ,Critical care medicine ,vol.11,pp.:660-663,Jul 2004.
C. Drosten, S.Günther and W.Preiser, “Identification of a novel coronavirus in patients with severe acute respiratory syndrome”, The New England journal of medicine,vol.348,No.20,pp.1967-1976,May 2003.
Y. Huang and Z.Gao , “ Study of the relationship SARS and hepatitis virusB” ,Chin J Clini Hepatol, vol. 19,No.6, pp.342-343,Jun 2003.
J. Wang, W.Sheng and C.Fang, , “Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients”, Emerging infectious diseases,vol.10,No.5,pp.818-824,May 2004.
T. Jiang, M.Zhao and Z. Zhou, “Clinical feature of liver injury in patients with severe acute respiratory syndrome”, Journal of Modern Medical Information Sciences, Vol.23, pp.139-141,2004 .
S. Lu, C.Lee and M.Lin, “Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome” ,The American journal of tropical medicine and hygiene ,vol.71,No.2,pp. 125-128,Aug 2004.
X. Duan,Z. Liu and R.He, “The dynamic change of liver injury in patients with severe acute respiratory syndrome”, Chinese journal of hepatology ,vol12,No.7,pp.439-460
J. Lu, J.Zhao and N.Li, “Ultrastructure pathology of all organs in severe acute respiratory syndrome” ,Chinese Journal of Diagnostic Pathology, vol.4, p.72-77,Apr 2003.
Y. Ding, L.He and Q.Zhang, “Organ distribution of severe acute;2 respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways” ,The Journal of pathology, vol.203, No.2 ,pp.622-630,Jun 2004.
G.Farcas, S.Poutanen and T. Mazzulli, “Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus” ,The Journal of Infectious Diseases ,vol.191, No.2,pp.193-197,Jun 2005.
W. Li, M.Moore and N.Vasilieva, “Angiotensin-converting enzyme2 is a functional receptor for the SARS coronavirus” ,Nature ,vol.426, No.965, pp.450-454,Apr 2004.
I. Hamming, W.Timens,M. Bulthuis, A.Lely,G. Navis, H.van Goor ,et al., “ Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis”, The Journal of pathology ,vol.203,No.2,pp.631-637,Jun 2004.
Y. Tan, B.Fielding and P.Goh, “Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndromecoronavirus, induces apoptosis via a caspase-dependent pathway”, Journal of Virology, vol.78,No.24,pp.14043-14047,Dec 2004.
V. Raj, H. Mou, S. Smits, D. Dekkers, M. Müller, R. Dijkman, et al., “ Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC” Nature, vol.495,No.7440, pp.251–254,Feb 2013 .
M. Saad, A. Omrani, K. Baig, A. Bahloul, F. Elzein, M. Matin, et al., “Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia ”, International journal of infectious diseases,vol. 29,pp. 301–306, Dec 2014.
D. Ng, F. Al Hosani, M. Keating, S. Gerber, T. Jones, M. Metcalfe, et al., “ Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates. April 2014”, The American journal of pathology ,vol.186,No.3,pp. 652–658,Mar 2016.
Y. Arabi, A. Al-Omari, Y. Mandourah, F. Al-Hameed, A. Sindi, B. Alraddadi, et al., “ Critically ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study” , Critical care medicine,vol.45,No.10,pp. 1683–1695,Oct 2017.
A. Assiri, J. Al-Tawfiq, A. Al-Rabeeah, F. Al-Rabiah, S. Al-Hajjar, A. Al- Barrak, et al., “Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study” ,Lancet Infectious Disease ,vol13,No.9,pp.752–761,Aug 2013.
Y. Arabi , A. Arifi , H. Balkhy, H. Najm, A. Aldawood, A. Ghabashi, et al., “Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection” ,Annals of internal medicine ,vol,160,No.6, pp.389–397,Mar 2014.
