Effect of Covid-19 Vaccine on Women's Fertility Hormones

Haydar Basim Najeb; Abdulameer Jasim Mohammed; Emad Mohammed Rasheed

doi:10.51173/jt.v4i33.738

Authors

Haydar Basim Najeb College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, Iraq
Abdulameer Jasim Mohammed College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, Iraq
Emad Mohammed Rasheed Institute of Medical Technology / Mansour, Middle Technical University, Baghdad, Iraq

DOI:

https://doi.org/10.51173/jt.v4i33.738

Keywords:

Covid-19 vaccine, Female hormone, FSH, LH, Prolactin

Abstract

The coronavirus disease 2019 (COVID-19), as a result of the modern intense respiratory syndrome coronavirus 2, caused an unexpected fundamental global raise in the admission to hospitals for lung and other organ diseases. COVID-19 vaccination has increased and accelerated in a conscionable progress. More than 184 nominee vaccines are being tested in preclinical use and 104 in clinical stages of development. The current study aimed to know the impact of the COVID-19 vaccine on female fertility hormones. The results obtained from the current study showed a slight increase in FSH and LH hormones for women infected with Covid-19 virus and for women who received the vaccine to prevent covid-19 virus compared to healthy, uninfected and unvaccinated groups (FSH 10.26±3.86 ,15.32±2.04 LH 15.41±2.76, 10.40±1.58 respectively), with non-significant differences (P>0.05), while the prolactin hormone levels showed a highly significant increase (P<0.01) in infected women who took the vaccine in comparison with its levels in healthy women who did not receive the vaccine and not infected (32.32±6.48, 19.62±4.04, 10.27±6.88 respectively). Conclusions: Covid- 19 vaccine affected the female hormones in one way or another.

Downloads

Download data is not yet available.

References

W Joost Wiersinga , Andrew Rhodes , Allen C Cheng ,Sharon J Peacock , Hallie C Prescott (2020) Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A ReviewJAMA;324(8):782-793. doi: 10.1001/jama.2020.12839.

Evangelia Fouka, Ioannis Kalomenidis , Niki Gianniou, Sofia Gida, Paschalis Steiropoulos (2021) COVID-19 Advanced Care J Pers Med. 2021 Oct 25;11(11):1082. doi: 10.3390/jpm11111082.

W K Lam 1, N S Zhong, W C Tan (2003) Overview on SARS in Asia and the world Respirology ;8 Suppl(Suppl 1):S2-5. doi: 10.1046/j.1440-1843.2003.00516.x

Zheng, Z., Peng, F., Xu, B., Zhao, J., Liu, H., Peng, J., & Tang, W. (2020). Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. Journal of infection, 81(2), e16-e25.‏

Lami, F., Rashak, H. A., Khaleel, H. A., Mahdi, S. G., Adnan, F., Khader, Y. S. & Lehlewa, A. (2021). Iraq experience in handling the COVID-19 pandemic: implications of public health challenges and lessons learned for future epidemic preparedness planning. Journal of Public Health, 43(3), 19-28.‏

Zhu N, Zhang D,WangW, et al; (2019) China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China. N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017

W. Joost Wiersinga, ; Andrew Rhodes, ; Allen C. Cheng, ; Sharon J. Peacock, ; Hallie C. Prescott, (2020) Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)A Review JAMA.;324(8):782-793. doi:10.1001/jama.12839

Sagheer Ahmed , Saeed Khan , Imran Imran , Fadwa Al Mughairbi , Fahad Sultan Sheikh , Javid Hussai , Ajmal Khan and Ahmed Al-Harrasi (2021) Vaccine Development against COVID-19: Study from Pre-Clinical Phases to Clinical Trials and Global Use Vaccines. 9, 836

Duduzile N. dwandwe and Charles S.Wiysonge (2021) Current Opinion in Immunology Volume 71, COVID-19 vaccines Pages 111-116

Cahoreau C, Klett D, Combarnous Y (2015). "Structure-function relationships of glycoprotein hormones and their subunits' ancestors". Frontiers in Endocrinology. 6:26 doi:10.3389/fendo.2015.00026.

Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (1998). "Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice". Endocrine Reviews. 19 (3): 225–68. doi:10.1210/edrv.19.3.0334. PMID 9626554

M E Freeman, B Kanyicska, A Lerant, G Nagy (2000) Prolactin: structure, function, and regulation of secretion National library of medicine , national center of biotechnology information 80(4):1523-631. doi: 10.1152/physrev.2000.80.4.1523.

Fei Chen , Shiheng Zhu, Zhiqing Dai, Lanting Hao, Chun Luan, Qi Guo, Chaofan Meng, and Yankun Zhang (2021) Effects of COVID-19 and mRNA vaccines on human fertility Human Reproduction, pp. 1–9, 2021 https://doi.org/10.1093/humrep/deab238.

Carp-Veliscu, Claudia Mehedintu , Francesca Frincu , Elvira Bratila , Simona Rasu , Ioana Iordache , Alina Bordea and Mihaela Braga (2022) Review The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature Andreea Int. J. Environ. Res. Public Health , 19, 984

Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, Ya-Bin L, Yang G, Fei C. Potential influence of COVID-19/ACE2 on the female reproductive system. Mol Hum Reprod 2020;26:367–373.

Li, K.; Chen, G.; Hou, H.; Liao, Q.; Chen, J.; Bai, H.; Lee, S.; Wang, C.; Li, H.; Cheng, L.; et al. (2021) Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. RBMO, 42, 260–267.

Martel, R.A.; Shaw, J.; Blakemore, J.K.(2021) Trends in FSH levels and cycle completion rates in women undergoing assisted reproductive technology (AST) before and during the COVID-19 pandemia. Fertil. Steril. 116 (Suppl. 1), e33.

Ding, T.; Wang, T.; Zhang, J.; Cui, P.; Chen, Z.; Zhou, S.; Yuan, S.; Ma, W.; Zhang, M.; Rong, Y.; et al. (2021) Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study. Front. Med. 8, 6.