Studying Some Factors That Increase the Risk of Thalassemia in The City of Baquba
DOI:
https://doi.org/10.51173/jt.v4i33.947Keywords:
Thalassemia, Hemoglobin, Hemolytic Anemia, GenesAbstract
In the current study, 200 cases with thalassemia (111 males and 89 females) were used. Case samples were obtained from persons listed for Baquba Teaching Hospital / Hematology Center from November 1st, 2019 to January 31, 2020. Data were taken from patients' get-in hospital clinical reports through a form prepared for collecting data. The study aims to measure the impact of some factors on Thalassemia. The results showed that there is an effect of the relationship between chronological age and getting the disease, as it was found that the highest percentage was within the age group (1-10) years. It was also found that the number of males carry the disorder is higher than the number of infected females. Also, the effect of the type of Thalassemia factor on the infection of the disease shows that those who carry thalassemia major are more affected than those who carry thalassemia intermedia. The effect of the blood type factor on the infection rate shows that the highest number of infected people was those with blood type O. The effect of the disease history factor on the infection of the disease shows that the category (less than one year old) is more likely to get the disease. The effect of the factor of the number of infections in the family shows that the category (there are no previous infections in the family) are more numerous.
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Dedousis GVZ, Mandilara GD, Boussin M. Loutradis.(2000). Hb production beta thalassemia. Wiley-liss Inc. 2000;646:151–5.
Rich, S.A., Ziegler, F.D., & Grimley, P.M. (2002). Prevention of homozygous beta thalassemia by carrier screening in pregnancy. Haema, 5 (3), p.p. 242-245.
CAPPELLINI, M.D., COHEN, A., PORTER, J., TAHER, A. and VIPRAKASIT, V., 2014. Guidelines for the management of transfusion dependent thalassaemia (TDT). Nicosia, Cyprus: Thalassaemia International Federation, pp. 148-149.
BURMESTER, T. and HANKELN, T., 2014. Function and evolution of vertebrate globins. Acta Physiologica (Oxford, England), vol. 211, no. 3, pp. 501-514. http://dx.doi.org/10.1111/apha.12312. PMid:24811692.
Sankaran VG, Nathan DG, Orkin SH. Thalassemias. In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux S (eds) Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. Eight Edition. Elsevier. PA, USA. 2015;715-769.
Ünal Ş, Gümrük F. The Hematological and molecular spectrum of α-thalassemias in Turkey: The Hacettepe Experience. Turk J Haematol. 2015;32(2):136-43. https://doi.org/10.4274/tjh.2014.0200
Aydınok Y, Oymak Y, Atabay B, et al. A national registry of thalassemia in Turkey: Demographic and disease characteristics of patients, achievements, and challenges in prevention. Turk J Haematol. 2018;35(1):12-8.
Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT). Cappellini MD, Cohen A, Porter J, Taher A, Viprakasit V. 3rd ed. Thalassaemia International Federation TIF Publication No. 20.
Ryan K, Bain BJ, Worthington D, James J, Plews D, Mason A, et al. Significant haemoglobinopathies: guidelines for screening and diagnosis. Br J Haematol 2010;149:35-49
Vichinsky EP. Alpha thalassemia major—new mutations, intrauterine management, and outcomes. Hematology Am Soc Hematol Educ Program 2009;1:35-41.
Cao A. Carrier screening and genetic counselling in beta-thalassemia. Int J Hematol 2002;76(Suppl 2):105-13.
Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001;22:2171-9.
Olivieri NF, Brittenham GM, Matsui D, Berkovitch M, Blendis LM, Cameron RG, et al. Iron-chelation therapy with oral deferiprone in patients with thalassemia major. N Engl J Med 1995;332:918-22.
Muncie Jr HL, Campbell JS. Alpha and beta thalassemia. Am Fam Physician. 2009;80(4):339–44.
Singer ST. Variable clinical phenotypes of α-thalassemia syndromes. ScientificWorldJournal. 2009;9:615–25.
Mikael NA, Al-Allawi NAS. Factors affecting quality of life in children and adolescents with thalassemia in Iraqi Kurdistan. Saudi Med J. 2018;39(8):799.
Hassan AN. Molecular and Some Hematological Investigations of β-thalassemic Children in Erbil Governorate. PhD, Salahaddin Univ Erbil. 2016;
Abid QH, Ereiby AM. Study of relationship between thalassemia disease and blood groups, weight and some of blood parameters. Drug Invent Today. 2019;11(11).
Nebeker JR, Hoffman JM, Weir CR, Bennett CL, Hurdle JF. High rates of adverse drug events in a highly computerized hospital. Arch Intern Med. 2005;165(10):1111–6.
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