Release of Copper / Magnesium Ions from Hydroxyapatite-Based Fiber Scaffolds Hasten Bone Healing and Regeneration

Adil Elrayah; Jie Weng; Dongqin Xiao; Azher S Barrak

doi:10.51173/jt.v6i3.2567

Authors

Adil Elrayah Medicine Collage, Karary University, Omdurman, 12304, Sudan
Jie Weng Key Laboratory of Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
Dongqin Xiao Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, 637000 China
Azher S Barrak Ozone NDT Consulting LLC, Fort Worth, Texas, USA

DOI:

https://doi.org/10.51173/jt.v6i3.2567

Keywords:

Scaffolds, Hydroxyapatite, Ions, Copper, Magnesium

Abstract

Releasing inorganic ions from Ca/P biomaterials could provide an alternative approach to using growth factors to improve bone healing. Two types of hydroxyapatite HA fiber scaffolds, copper-doped (CuHA) and magnesium-doped (MgHA), were fabricated by using the sol-gel method. Two types of scaffolds were immersed in simulated body fluid SPF (i,e, Phosphate Buffered Saline PBS) for 30 days. The results after immersions indicated the amount of Cu and Mg ions released from scaffolds. A low amount of Mg and Cu ions could improve vascular endothelial growth factor (VEGF) and angiogenesis around bone, thus can hasten bone healing and regeneration.

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Author Biographies

Adil Elrayah, Medicine Collage, Karary University, Omdurman, 12304, Sudan

Jie Weng, Key Laboratory of Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China

Dongqin Xiao, Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, 637000 China

Azher S Barrak, Ozone NDT Consulting LLC, Fort Worth, Texas, USA

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