The Comparison and Correlation of Serum Levels of Insulin and Na+/ K+ Atpase In Type 2 Diabetes Mellitus (T2DM) And Non-Diabetes Mellitus Individuals

Karar Kazem Mohammed; Ahmed Ghazi Sabbar; Haider Hafid Hmeash

doi:10.51173/jt.v4i3.540

Authors

Karar Kazem Mohammed College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, Iraq
Ahmed Ghazi Sabbar College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, Iraq
Haider Hafid Hmeash College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, Iraq

DOI:

https://doi.org/10.51173/jt.v4i3.540

Keywords:

Type 2 Diabetes Mellitus (T2DM), Insulin, Na /K ATPase, Hyperglycemia, Beta-cell

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition characterized by hyperglycemia that persists. Diabetes mellitus can cause damage to multiple organ systems, leading to the development of severe and life-threatening health issues, due to decreased insulin secretion, resistance to peripheral insulin effects, or both.

Objective: the comparison and correlation of serum levels of insulin and Na+/ K+ ATPase in T2DM and Non-Diabetic patients.

Material and methods: A case-control study was carried out in the max cure diabetes center and Al-Zahra Teaching Hospital in the city of AL-Kut, Iraq. Including 114 patients divided into 54 patients of T2DM in addition to 60 individuals as control (male and female), ages ranging from (20-70 years) from November 2021 –to March 2022. It was the measurement of serum Na+/K+ATPase and insulin level.

Results: In the comparison of insulin levels in Type 2 Diabetes Mellitus (T2DM) and healthy control group, serum insulin was found to be significantly decreased (p value<0.005) and Na+/K+ ATPase significantly decrease with a (p value<0.001) in diabetics as compared to control group. The correlation was positive and significant between the serum Na+/K+ ATPase and insulin.

Conclusions: serum insulin and Na+/K+ ATPase showed a significant decrease in diabetics as compared to the control group. Whereas a significant positive correlation is obtained between the parameters.

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